DISEASES

Disease-gene associations mined from literature

Literature on ATP5MPL

ATP5MPL [ENSP00000401770]

ATP synthase subunit ATP5MPL, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). Minor subunit required to maintain the ATP synthase population in the mitochondria ; Belongs to the small mitochondrial proteolipid family.

Synonyms:  ATP5MPL,  ATP5MPLp,  hATP5MPL,  A0A024R6N3,  A0A0A0MTQ5 ...

Linkouts:  STRING  Pharos  UniProt