DISEASES

Disease-gene associations mined from literature

Literature on CUX1

CUX1 [ENSP00000353401]

Homeobox protein cut-like 1; Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC- rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator; Belongs to the CUT homeobox family.

Synonyms:  CUX1,  CUX1p,  hCUX1,  A0A2R8Y852,  A0A2R8Y8D0 ...

Linkouts:  STRING  Pharos  UniProt