DISEASES

Disease-gene associations mined from literature

Literature on ATP5IF1

ATP5IF1 [ENSP00000335203]

ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.

Synonyms:  ATP5IF1,  ATP5IF1p,  hATP5IF1,  A0A0B4J230,  Q9UII2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM