DISEASES

Disease-gene associations mined from literature

Literature on PELI3

PELI3 [ENSP00000322532]

E3 ubiquitin-protein ligase pellino homolog 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation; Belongs to the pellino family.

Synonyms:  PELI3,  PELI3p,  hPELI3,  A0A024R5B1,  A0A024R5I2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM