Literature on ATXN7L3
ATXN7L3 [ENSP00000397259]
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B . The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex . Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B . Rule:MF_03047, ECO:0000269|PubMed:18206972,; Belongs to the SGF11 family.
Synonyms: ATXN7L3, ATXN7L3p, hATXN7L3, K7EJK2, K7EKG9 ...