DISEASES

Disease-gene associations mined from literature

Literature on SLA

SLA [ENSP00000394049]

Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Synonyms:  SLA,  E5RGG0,  E5RH80,  E5RHT2,  E5RJ69 ...

Linkouts:  STRING  Pharos  UniProt  OMIM