DISEASES

Disease-gene associations mined from literature

Literature on MEX3C

MEX3C [ENSP00000385610]

RNA-binding E3 ubiquitin-protein ligase MEX3C; E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Synonyms:  MEX3C,  MEX3Cp,  hMEX3C,  K7ER23,  M9T4I7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM