DISEASES

Disease-gene associations mined from literature

Literature on SIAH3

SIAH3 [ENSP00000383256]

Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. ; Belongs to the SINA (Seven in absentia) family.

Synonyms:  SIAH3,  SIAH3p,  hSIAH3,  Q8IW03,  Q8IW03p ...

Linkouts:  STRING  Pharos  UniProt  OMIM