DISEASES

Disease-gene associations mined from literature

Literature on LIMA1

LIMA1 [ENSP00000378400]

LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments . Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).

Synonyms:  LIMA1,  LIMA1p,  hLIMA1,  F8VQE1,  F8VRN8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM