DISEASES

Disease-gene associations mined from literature

Literature on KCNIP4

KCNIP4 [ENSP00000371587]

Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents . Isoform 4 does not increase KCND2 expression at the cell membrane . Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:18957440,; Belongs to the recoverin family.

Synonyms:  KCNIP4,  KCNIP4p,  hKCNIP4,  F5H395,  Q3YAB7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM