DISEASES

Disease-gene associations mined from literature

Literature on ASCC3

ASCC3 [ENSP00000358159]

Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation .

Synonyms:  ASCC3,  ASCC3p,  hASCC3,  E5RFZ0,  J3KNJ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM