DISEASES

Disease-gene associations mined from literature

Literature on PSPC1

PSPC1 [ENSP00000343966]

Paraspeckle component 1; Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway; Belongs to the PSPC family.

Synonyms:  PSPC1,  PSPC1p,  hPSPC1,  A0A024RDP4,  A0A0U1RQF9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM