DISEASES

Disease-gene associations mined from literature

Literature on RGS7BP

RGS7BP [ENSP00000334851]

Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.

Synonyms:  RGS7BP,  RGS7BPp,  hRGS7BP,  Q6MZT1,  Q6MZT1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM