DISEASES

Disease-gene associations mined from literature

Literature on ALG10B

ALG10B [ENSP00000310120]

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N- linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 . Has a role in maintenance of cochlear outer hair cell function (By similarity).

Synonyms:  ALG10B,  ALG10Bp,  hALG10B,  F8VWA9,  F8VXJ0 ...

Linkouts:  STRING  Pharos  UniProt