DISEASES

Disease-gene associations mined from literature

Literature on HES6

HES6 [ENSP00000272937]

Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation (By similarity).

Synonyms:  HES6,  HES6p,  hHES6,  B8ZZP9,  B9A070 ...

Linkouts:  STRING  Pharos  UniProt  OMIM