Literature on RNF157
RNF157 [ENSP00000269391]
E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons . Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical . May act as a scaffold molecule to regulate this process . Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle .
Synonyms: RNF157, RNF157p, hRNF157, A0A3B3ISM3, K7EKB4 ...