DISEASES

Disease-gene associations mined from literature

Literature on LOXL3

LOXL3 [ENSP00000264094]

Lysyl oxidase homolog 3; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins . Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin . Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity . Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated . Also able to catalyze deacetylation of lysine residues on STAT3 . [Isoform 2]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV .

Synonyms:  LOXL3,  LOXL3p,  hLOXL3,  B8ZZT6,  B9A025 ...

Linkouts:  STRING  Pharos  UniProt  OMIM