DISEASES

Disease-gene associations mined from literature

Literature on PARD6A

PARD6A [ENSP00000219255]

Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins . Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization ; Belongs to the PAR6 family.

Synonyms:  PARD6A,  PARD6Ap,  hPARD6A,  Q9NPB6,  R4GMM2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM