DISEASES

Disease-gene associations mined from literature

Literature on ESRP2

ESRP2 [ENSP00000418748]

Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Synonyms:  ESRP2,  ESRP2p,  hESRP2,  J3KRF2,  J3QKU3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM