DISEASES

Disease-gene associations mined from literature

Literature on TLK1

TLK1 [ENSP00000411099]

Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414,; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Synonyms:  TLK1,  TLK1p,  hTLK1,  B3KRP1,  C9JWT6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM