DISEASES

Disease-gene associations mined from literature

Literature on PIAS3

PIAS3 [ENSP00000376765]

E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 . Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus . ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032,; Belongs to the PIAS family.

Synonyms:  PIAS3,  PIAS3p,  hPIAS3,  E7ESB4,  E9PHH8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM