DISEASES

Disease-gene associations mined from literature

Literature on TRAF1

TRAF1 [ENSP00000362994]

TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin- protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455,

Synonyms:  TRAF1,  TRAF1p,  hTRAF1,  Q13077,  Q13077p ...

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