DISEASES

Disease-gene associations mined from literature

Literature on ARHGEF15

ARHGEF15 [ENSP00000355026]

Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2.

Synonyms:  ARHGEF15,  A0A0S2Z547,  A0A3B3IUF8,  J3KT46,  J3QQS4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM