DISEASES

Disease-gene associations mined from literature

Literature on GPATCH3

GPATCH3 [ENSP00000354645]

G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development . Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 .

Synonyms:  GPATCH3,  GPATCH3p,  hGPATCH3,  H0Y5H5,  Q5JYG5 ...

Linkouts:  STRING  Pharos  UniProt