DISEASES

Disease-gene associations mined from literature

Literature on TYW1

TYW1 [ENSP00000352645]

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

Synonyms:  TYW1,  TYW1p,  hTYW1,  A0A087WUV9,  C9J9Q4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM