DISEASES

Disease-gene associations mined from literature

Literature on ZC3HC1

ZC3HC1 [ENSP00000351052]

Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Synonyms:  ZC3HC1,  ZC3HC1p,  hZC3HC1,  C9J0I9,  F8WAU5 ...

Linkouts:  STRING  Pharos  UniProt