DISEASES

Disease-gene associations mined from literature

Literature on JAML

JAML [ENSP00000348635]

Junctional adhesion molecule-like; Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633,

Synonyms:  JAML,  A0A1W2PRS4,  E9PJJ4,  E9PKK2,  E9PLF9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM