DISEASES

Disease-gene associations mined from literature

Literature on ANAPC1

ANAPC1 [ENSP00000339109]

Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. ; Belongs to the APC1 family.

Synonyms:  ANAPC1,  ANAPC1p,  hANAPC1,  A0A2R8YF63,  F8WAS1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM