DISEASES

Disease-gene associations mined from literature

Literature on LRRC8D

LRRC8D [ENSP00000338887]

Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin . Mediates the import of the antibiotic blasticidin-S into the cell . ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26530471,

Synonyms:  LRRC8D,  LRRC8Dp,  hLRRC8D,  E9PJ89,  E9PJS7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM