DISEASES

Disease-gene associations mined from literature

Literature on KLHL25

KLHL25 [ENSP00000336800]

Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Synonyms:  KLHL25,  KLHL25p,  hKLHL25,  Q9H0H3,  Q9H0H3p ...

Linkouts:  STRING  Pharos  UniProt