DISEASES

Disease-gene associations mined from literature

Literature on ATG4C

ATG4C [ENSP00000322159]

Cysteine protease ATG4C; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Synonyms:  ATG4C,  ATG4Cp,  hATG4C,  A0A384MTY5,  A6NGQ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM