DISEASES

Disease-gene associations mined from literature

Literature on CAMKK2

CAMKK2 [ENSP00000312741]

Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496,

Synonyms:  CAMKK2,  CAMKK2p,  hCAMKK2,  A0A024RBP6,  A0A024RBP8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM