DISEASES

Disease-gene associations mined from literature

Literature on NDST2

NDST2 [ENSP00000310657]

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan . ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444,

Synonyms:  NDST2,  NDST2p,  hNDST2,  H7C032,  P52849 ...

Linkouts:  STRING  Pharos  UniProt  OMIM