DISEASES

Disease-gene associations mined from literature

Literature on NLRP4

NLRP4 [ENSP00000301295]

NACHT, LRR and PYD domains-containing protein 4; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4- mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Synonyms:  NLRP4,  NLRP4p,  hNLRP4,  K7ES09,  K7ESK5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM