DISEASES

Disease-gene associations mined from literature

Literature on GRID2

GRID2 [ENSP00000282020]

Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber- Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily.

Synonyms:  GRID2,  GRID2p,  hGRID2,  A0A087X043,  A0A1B0GW49 ...

Linkouts:  STRING  Pharos  UniProt  OMIM