DISEASES

Disease-gene associations mined from literature

Literature on PLA1A

PLA1A [ENSP00000273371]

Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. ; Belongs to the AB hydrolase superfamily. Lipase family.

Synonyms:  PLA1A,  PLA1Ap,  hPLA1A,  G5E9W0,  H7C4H1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM