DISEASES

Disease-gene associations mined from literature

Literature on PAPSS1

PAPSS1 [ENSP00000265174]

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells . ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,

Synonyms:  PAPSS1,  PAPSS1p,  hPAPSS1,  O43252,  O43252p ...

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