DISEASES

Disease-gene associations mined from literature

Literature on PARP16

PARP16 [ENSP00000261888]

Protein mono-ADP-ribosyltransferase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors . May also mediate mono-ADP- ribosylation of karyopherin KPNB1 a nuclear import factor . May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases .

Synonyms:  PARP16,  PARP16p,  hPARP16,  H3BV75,  Q8N5Y8 ...

Linkouts:  STRING  Pharos  UniProt