DISEASES

Disease-gene associations mined from literature

Literature on USPL1

USPL1 [ENSP00000255304]

SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full- length SUMO proteins to their mature forms . Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies . Is a component of complexes that can bind to U snRNA genes .

Synonyms:  USPL1,  USPL1p,  hUSPL1,  Q5W0Q7,  Q5W0Q7p ...

Linkouts:  STRING  Pharos  UniProt