DISEASES

Disease-gene associations mined from literature

Literature on HELB

HELB [ENSP00000247815]

DNA helicase B; 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB . As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation . Acts independently of TP53BP1 . Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates . During S phase, may facilitate cellular recovery from replication stress . ; Belongs to the RecD family. HELB subfamily.

Synonyms:  HELB,  F5H1I4,  Q8NG08,  F5H1I4p,  hF5H1I4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM