DISEASES

Disease-gene associations mined from literature

Literature on LMCD1

LMCD1 [ENSP00000157600]

LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Synonyms:  LMCD1,  LMCD1p,  hLMCD1,  B4DEY6,  C9IYS1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM