DISEASES

Disease-gene associations mined from literature

Literature on OTUD5

OTUD5 [ENSP00000156084]

OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).

Synonyms:  OTUD5,  OTUD5p,  hOTUD5,  A0A024QZ09,  A0A087WXV6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM