DISEASES

Disease-gene associations mined from literature

Literature on PPP6C

PPP6C [ENSP00000392147]

Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed; Catalytic subunit of protein phosphatase 6 (PP6) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 . During mitosis, regulates spindle positioning . Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 . Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG- I/DDX58-mediated signaling activation . ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:27335426,; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.

Synonyms:  PPP6C,  PPP6Cp,  hPPP6C,  A0A024R861,  O00743 ...

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