DISEASES

Disease-gene associations mined from literature

Literature on TP53RK

TP53RK [ENSP00000361186]

EKC/KEOPS complex subunit TP53RK; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 . TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation . ECO:0000250|UniProtKB:Q9UYB9, ECO:0000269|PubMed:11546806,

Synonyms:  TP53RK,  TP53RKp,  hTP53RK,  Q5JZ02,  Q96S44 ...

Linkouts:  STRING  Pharos  UniProt  OMIM