DISEASES

Disease-gene associations mined from literature

Literature on MYO6

MYO6 [ENSP00000358994]

Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments . Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway . Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells . May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton . May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription . ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995,; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Synonyms:  MYO6,  MYO6p,  hMYO6,  A0A0A0MRM8,  A0A0D9SGC1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM