DISEASES

Disease-gene associations mined from literature

Literature on FBXL5

FBXL5 [ENSP00000344866]

F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Synonyms:  FBXL5,  FBXL5p,  hFBXL5,  D6R9Y4,  D6RB50 ...

Linkouts:  STRING  Pharos  UniProt  OMIM