DISEASES

Disease-gene associations mined from literature

Literature on SPTSSA

SPTSSA [ENSP00000298130]

Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA . Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI) .

Synonyms:  SPTSSA,  Q969W0,  Q969W0p,  hQ969W0,  171546 ...

Linkouts:  STRING  Pharos  UniProt