DISEASES

Disease-gene associations mined from literature

Literature on NCAPH

NCAPH [ENSP00000240423]

Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases . Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size . ; Belongs to the CND2 (condensin subunit 2) family.

Synonyms:  NCAPH,  C9J470,  C9JZP1,  E9PHA2,  H7C415 ...

Linkouts:  STRING  Pharos  UniProt  OMIM