DISEASES

Disease-gene associations mined from literature

Literature on RAPGEF4

RAPGEF4 [ENSP00000380271]

Rap guanine nucleotide exchange factor 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).

Synonyms:  RAPGEF4,  RAPGEF4p,  hRAPGEF4,  B7Z278,  E9PB94 ...

Linkouts:  STRING  Pharos  UniProt  OMIM