DISEASES

Disease-gene associations mined from literature

Literature on DIS3L

DIS3L [ENSP00000321711]

DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Synonyms:  DIS3L,  DIS3Lp,  hDIS3L,  E9PI20,  E9PI27 ...

Linkouts:  STRING  Pharos  UniProt  OMIM